Reliable disease biomarkers Identifying and Characterizing electrohypersensitivity and multiple chemical sensitivity as two aspects of a single etiopathogenic pathological disorder
Dominique Belpomme 1, 2 / Christine Campagnac 2, 3 / Philippe Irigaray 2, 4
1 Paris V University Hospital, France
2 European Cancer and Environment Research Institute (ECERI), Brussels, Belgium
3 Hospital Director, seconded from Publique-Hôpitaux de Paris (AP-HP), Paris, France
4 Association for Research and Treatments Against Cancer (ARTAC), F-75015 Paris, France
Corresponding author: Philippe Irigaray, PhD, ARTAC, 57-59 rue de la Convention, 75015 Paris, Phone: +33 (0) 1 45 78 53 54, Fax: +33 (0) 1 45 78 53 50, E-mail : (e); Association for Research and Treatments Against Cancer (ARTAC), F-75015 Paris, France; and European Cancer and Environment Research Institute (ECERI), Brussels, Belgium
Citation Information: Reviews on Environmental Health. Volume 30, Issue 4, Pages 251-271, ISSN (Online) 2191-0308, ISSN (Print) from 0048 to 7554, DOI: 10.1515 / reveh-
Publication History
Abstract
Much of the controversy over the causes of electro-hypersensitivity (EHS) and multiple chemical sensitivity (MCS) lies in the lack of Both reconnu objective clinical criteria and biomarkers for diagnosis Widely accepted. Since 2009, we prospectively-have Investigated, Clinically and biologically, 1216 consecutive EHS and / or MCS self-reporting boxes, in an Attempt to answer Both issues. We report here our preliminary data, we based Enrolled 839 of 727 evaluable cases: 521 (71.6%) Were Diagnosed with EHS, 52 (7.2%) with MCS, and 154 (21.2%) with Both EHS and MCS. Two out of three patients with EHS and / or MCS Were female; mean age (years) 47. Was As inflammation Appears to be a key process resulting and from electromagnetic field (EMF) and / or chemical effects are tissues, and histamine release is Potentially a major mediator of inflammation, we Measured Systematically histamine in the blood of patients. Near Had a 40% Increase in histaminemia (Especially When Were Both circumstances present), a chronic inflammatory response indicating indication can be detected in patients thesis. Oxidative stress is inflammation of hand and is a key contributor to damage and response. Nitrotyrosin, a marker of Both peroxynitrite (ONOO ° -) Production and opening of the blood-brain barrier (BBB) Was Increased 28% in the boxes. Protein S100B, Reviews another marker of BBB opening Was Increased in 15%. Circulating autoantibodies contre O-myelin Were detected in 23%, indicating indication EHS and MCS May be associated with autoimmune response. Confirming animal experiments showing the Increase of Hsp27 and / or Hsp70 chaperone proteins under the effect of EMF, we found Increased Hsp27 and / or Hsp70 in 33% of the patients. Most patients have chronic insomnia Reported and fatigue, we Determined the 24-h urine hydroxymelatonin 6 sulfate (6-OHMS) / ratio and found Creatinin It was Decreased (<0 .8="" all="" boxes.="" font="" in="" investigated="">Finally, Considering the self-Reported symptoms of EHS and MCS, we serially Measured the brain blood flow (BBF) in the temporal lobes of the cerebral Each box with pulsed ultrasound computed tomosphygmography. Were Both disorders associated with hypoperfusion in the area capsulothalamic, Suggesting que la inflammatory process Involve the limbic system and the thalamus. Our data suggest Strongly That EHS and MCS can be objectively and caractérisé Routinely Diagnosed by Commercially available single tests. Both disorders APPEAR to Involve histaminemia hyper-inflammation-related, oxidative stress, autoimmune response, capsulothalamic hypoperfusion and BBB opening, and a deficiency in melatonin metabolic availability; Suggesting a risk of chronic neurodegenerative disease. Finally the common co-occurrence of EHS and MCS Strongly Suggests a common pathological mechanism.
Keywords: biomarkers, cerebral hypoperfusion; electrohypersen
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