Tuesday, April 28, 2015

Study shows WAVEFORM more Important than Dosage

Le 2015-04-27 à 14:37, Evelyn Savarin a écrit :


Came across this Study and felt important to pass on. Although study was performed using 50 HZ fields It confirms the importance of Waveform even more than Dosage  in adverse EMF Studies. Could help explain Negative or Non- adverse effect EMF - RF studies, as well as beneficial effects EMF studies.

Evelyn Savarin

Bioelectromagnetics. 2014 Jan;35(1):30-8. doi: 10.1002/bem.21794. Epub 2013 Jun 17.

Different electromagnetic field waveforms have different effects on proliferation, differentiation and mineralization of osteoblasts in vitro.

Noninvasive electromagnetic fields (EMFs) have been known to be able to improve bone health; however, their optimal application parameters and action mechanisms remain unclear. This study compared the effects of different forms of EMFs (sinusoidal, triangular, square, and serrated, all set at 50Hz frequency and 1.8mT intensity) on proliferation, differentiation and mineralization of rat calvarial osteoblasts. Square EMFs stimulated osteoblast proliferation but sinusoidal EMFs inhibited it. Sinusoidal and triangular EMFs produced significantly greater alkaline phosphatase (ALP) activity, ALP staining areas, calcium deposition, mineralized nodule areas, and mRNA expression of Runx-2, osteoprotegerin and insulin-like growth factor-I than square and serrated EMFs (P<0.01). Triangular EMFs had a greater effect than sinusoidal EMFs on every indices except for Runx-2 mRNA expression (P<0.05). These results indicated that while square EMFs promoted proliferation and had no effect on the differentiation of osteoblasts, sinusoidal EMFs inhibited proliferation but enhanced osteogenic differentiation. Triangular EMFs did not affect cell proliferation but induced the strongest osteogenic activity among the four waveforms of EMFs. Thus, the effects of EMFs on proliferation and differentiation of osteoblasts in vitro were dependent on their waveforms.
Copyright © 2013 Wiley Periodicals, Inc.

Thanks, Evelyn

Andre Fauteux, Editor
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