: Nature's Physiologi c Calcium Blocker". American Heart Journal
- Calcium flooding into a blood vessel endothelial cell, will trigger off a signalling cascade that will lead to increased vascular tone (increased blood pressure)174.
- With low intakes or magnesium or insulin resistance or both, extracellular (blood) and intracellular levels of magnesium will be compromised (see below).
- Suboptimally low extracellular levels of magnesium will allow the calcium channels to stay open allowing an influx of calcium into cells. Having an optimal level of magnesium, allows this mineral to act as a calcium channel blocker.
- As mentioned above, suboptimal intakes of magnesium will result in unopposed influx of calcium leading to increasing intracellular calcium levels.