Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats
Bodera P, Stankiewicz W, Antkowiak B, Paluch M, Kieliszek J, Sobiech J, Niemcewicz M. Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats. Int J Occup Med Environ Health. 2015;28(4):751-9. doi: 10.13075/ijomeh.1896.00255
OBJECTIVES: The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment.
MATERIAL AND METHODS: The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund's adjuvant (CFA)-induced persistent paw inflammation.
RESULTS: The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund's adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly.
CONCLUSIONS: The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.
The electric field strength in terms of the RMS value was 20 V/m and the frequency was equivalent to 1800 MHz.
The values of the SAR varied from 0.024 to 0.028 W/kg.
The generator produced 1800 MHz carrier wave with pulse modulation (0.577 ms duration, repeating every 1.14 ms). The method utilized by the GSM is a combination of time- and frequency-division multiple access (TDMA and FDMA).
The obtained results suggest that exposure to the EMF slightly increases tissue lipid peroxidation in some tissues, especially in brain and kidneys in adult healthy rats and rats with inflammation.
Administration of tramadol together with the EMF exposure enhanced lipid peroxidation in kidneys, blood, and brain, both in healthy rats and those with inflammation, which was similar to the results of our previous study carried out by another method.
It can be concluded that the increased risk of oxidative stress in various organs due to electromagnetic radiation should be taken into account. However, this risk burden is probably determined by the duration of exposure, SAR and also additional environmental factors.
Joel M. Moskowitz, Ph.D., Director
Center for Family and Community Health
School of Public Health
University of California, Berkeley
Electromagnetic Radiation Safety
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