Friday, July 11, 2014

Lifestyle Risk Factors Associated with Threatened Miscarriage: A Case-Control Study

Lifestyle Risk Factors Associated with Threatened Miscarriage: A Case-Control Study

Tan TC1,4*, Neo GH1, Malhotra R2,3, Allen JC2, Lie D1 and Østbye T2,3
1Duke-NUS Graduate Medical School, Singapore
2Programme in Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore
3Duke Global Health Institute, Duke University, Durham, Singapore
4Department of O & G. KK Women’s and Children’s Hospital, Singapore
Corresponding Author :Tan Thiam Chye
KK Women’s and Children’s Hospital
100 Bukit Timah Road, Singapore
Tel: +65 62934044
Fax: +65 62986343
Received April 29, 2014; Accepted May 28, 2014; Published May 30, 2014
Citation: Tan TC, Neo GH, Malhotra R, Allen JC, Lie D, et al. (2014) Lifestyle Risk Factors Associated with Threatened Miscarriage: A Case-Control Study. JFIV Reprod Med Genet 2:123. doi: 10.4172/jfiv.1000123
Copyright: © 2014 Tan TC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
Visit for more related articles at 
DownloadJournal of Fertilization: In Vitro
Background: Threatened miscarriage occurs in 20% of pregnancies. We conducted a case-control study to assess the association between maternal lifestyle factors and risk of threatened miscarriage.

Methods: Cases were 154 women presenting with threatened miscarriage in the 5th to 10th weeks of gestation; controls were 264 women without threatened miscarriage seen in antenatal clinic in the 5th to 10th week of pregnancy. Lifestyle variables were: current and past cigarette smoking, current second-hand cigarette smoke exposure, computer and mobile-phone use, perceived stress, past contraceptive use, past menstrual regularity and consumption of fish oils, caffeine and alcohol. Logistic regression was performed.

Results: In multivariate analysis, we found a positive association of threatened miscarriage with second-hand smoke exposure (OR 2.93, 95% CI 1.32–6.48), computer usage (>4 hours/day) (OR 6.03, 95% CI 2.82–12.88), mobile-phone usage (>1 hour/day) (OR 2.94 95% CI 1.32–6.53) and caffeine consumption (OR 2.95 95% CI 1.57–5.57). Any fish oil consumption was associated with reduced risk of threatened miscarriage (OR 0.20, 95% CI 0.09–0.42).

Conclusions: Prolonged mobile phone and computer use and fish oil supplementation are potential novel correlates of threatened miscarriage that deserve further study.

No comments:

Post a Comment