Long term and excessive use of 900 MHz radiofrequency radiation alter microrna expression in brain

Long term and excessive use of 900 MHz radiofrequency radiation alter microrna expression in brain

Dasdag S, Akdag MZ, Erdal ME, Erdal N, Ay OI, Ay ME, Yilmaz SG, Tasdelen B, Yegin K. Long term and excessive use of 900 MHz radiofrequency radiation alter microrna expression in brain. 
Int J Radiat Biol. 2014 Dec 20:1-22. [Epub ahead of print].

Abstract

Purpose: We still do not have any information on the interaction between radiofrequency radiation (RF) and miRNAs, which play paramount role in growth, differentiation, proliferation and cell death by suppressing one or more target genes. The purpose of this study is to bridge this gap by investigating effects of long term 900 MHz mobile phone exposure on some of the miRNAs in brain tissue. 

Materials and Methods: The study was carried out on fourteen Wistar Albino adult male rats by dividing them into two groups: sham (n: 7) and exposure (n: 7). Rats in the exposure group were exposed to 900 MHz RF radiation for 3 h per day (7 d a week) for twelve months (one year). The same procedure was applied to the rats in the sham group except the generator was turned off. Immediately after the last exposure, rats were sacrificed and their brains were removed. rno-miR-9-5p, rno-miR-29a-3p, rno-miR-106b-5p, rno-miR-107 and rno-miR-125a-3p in brain were investigated in detail. 

Results: Results revealed that long term exposure of 900 MHz RF radiation only decreased rno-miR107 (adjP*= 0,045) value where the whole body (rms) SAR value was 0.0369 W/kg. However, our results indicated that other micro RNAs evaluated in this study was not altered by 900 MHz RF radiation. 

Conclusion: 900 MHz RF radiation can alter some of the miRNAs, which, in turn, may lead to adverse effects. Therefore, further studies should be performed.

http://1.usa.gov/1xIgjVl

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Joel M. Moskowitz, Ph.D., Director
Center for Family and Community Health
School of Public Health
University of California, Berkeley

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